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Basal-like breast carcinoma

MedGen UID:
770987
Concept ID:
C3642347
Neoplastic Process
Synonyms: Basal-Like Breast Cancer; basal-like breast cancer; Basal-Like Breast Carcinoma; basal-like breast carcinoma; Basal-Like Subtype of Breast Carcinoma; basal-like subtype of breast carcinoma
 
Monarch Initiative: MONDO:0004984

Definition

A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasal-like breast carcinoma

Professional guidelines

PubMed

Altundag K, Dede DS, Purnak T
J Clin Pathol 2007 Aug;60(8):958. doi: 10.1136/jcp.2006.042481. PMID: 17660346Free PMC Article

Recent clinical studies

Etiology

Sternemalm J, Russnes HG, Zhao X, Risberg B, Nord S, Caldas C, Børresen-Dale AL, Stokke T, Patzke S
Br J Cancer 2014 Jul 15;111(2):326-38. Epub 2014 Jun 5 doi: 10.1038/bjc.2014.297. PMID: 24901235Free PMC Article
Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
Bohn OL, Fuertes-Camilo M, Navarro L, Saldivar J, Sanchez-Sosa S
Int J Clin Exp Pathol 2010 Jun 30;3(6):600-7. PMID: 20661408Free PMC Article
Hasegawa M, Moritani S, Murakumo Y, Sato T, Hagiwara S, Suzuki C, Mii S, Jijiwa M, Enomoto A, Asai N, Ichihara S, Takahashi M
Pathol Int 2008 May;58(5):288-94. doi: 10.1111/j.1440-1827.2008.02225.x. PMID: 18429827

Diagnosis

Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
Haupt B, Ro JY, Schwartz MR
Arch Pathol Lab Med 2010 Jan;134(1):130-3. doi: 10.5858/134.1.130. PMID: 20073617
Rakha EA, Reis-Filho JS, Ellis IO
Pathobiology 2008;75(2):95-103. Epub 2008 Jun 10 doi: 10.1159/000123847. PMID: 18544964
Hasegawa M, Moritani S, Murakumo Y, Sato T, Hagiwara S, Suzuki C, Mii S, Jijiwa M, Enomoto A, Asai N, Ichihara S, Takahashi M
Pathol Int 2008 May;58(5):288-94. doi: 10.1111/j.1440-1827.2008.02225.x. PMID: 18429827

Therapy

Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S, Clement MV
Antioxid Redox Signal 2014 May 20;20(15):2326-46. Epub 2013 Nov 14 doi: 10.1089/ars.2013.5295. PMID: 23964924Free PMC Article
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801

Prognosis

Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
Haupt B, Ro JY, Schwartz MR
Arch Pathol Lab Med 2010 Jan;134(1):130-3. doi: 10.5858/134.1.130. PMID: 20073617
Rakha E, Reis-Filho JS
Arch Pathol Lab Med 2009 Jun;133(6):860-8. doi: 10.5858/133.6.860. PMID: 19492878
Rakha EA, Reis-Filho JS, Ellis IO
Pathobiology 2008;75(2):95-103. Epub 2008 Jun 10 doi: 10.1159/000123847. PMID: 18544964

Clinical prediction guides

Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Wijesinghe HD, Fernando J, Senarath U, Wijesinghe GK, S Lokuhetty MD
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):388-396. doi: 10.4103/IJPM.IJPM_657_19. PMID: 32769327
Guan B, Li Q, Shen L, Rao Q, Wang Y, Zhu Y, Zhou XJ, Li XH
Int J Oncol 2016 Aug;49(2):720-34. Epub 2016 Jun 8 doi: 10.3892/ijo.2016.3573. PMID: 27278159
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
Cakir A, Gonul II, Uluoglu O
Diagn Pathol 2012 Oct 20;7:145. doi: 10.1186/1746-1596-7-145. PMID: 23082819Free PMC Article

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